Toivo E. Rist, M.D., Emeritus

Toivo E. Rist, M.D., Emeritus

Biographic:

Address:
Business: Dermatology Associates of Knoxville, PC
939 Emerald Ave., Suite 705
Knoxville, Tennessee 37917
1977-Present

11416 Grigsby Chapel Road, Suite 100
Knoxville, Tennessee 37934

7557 Dannaher Way, Suite G20
Powell, TN 37849

Education:

High School: Southwest High School
Atlanta, Georgia
Graduated 1963

College: Emory University
Atlanta, Georgia
Graduated 1966 - B.A.

Medical: Medical College of Georgia
Graduated 1970 - M.D.

Intern: USAF Medical Center
Kessler AFB, MS 1970 - 1971

Residency: Medical College of Georgia
Hospitals and Clinics
1971 - 1974

Board:

State of Tennessee Medical License # MD0000010456
Certified American Board of Dermatology in 1975

Hospital Staff:

St. Mary's Medical Center, Fort Sanders Parkwest Medical Center, Fort Sanders Regional Medical Center, and East Tennessee Children's Hospital. (All hospitals are in Knoxville, Tennessee.)

Member:

Knoxville Academy of Medicine
Tennessee Medical Association
American Medical Association
American Academy of Dermatology
Southern Medical Association
Association of Military Dermatologists
Tennessee Dermatology Society
American Society for Laser Medicine and Surgery
International Society of Dermatologic Surgery

Academic Positions:

Clinical Instructor, Dermatology, University of Alabama Medical Center, 1974 - 1976

Assistant Clinical Professor, Dermatology, University of Texas Health Science Center at San Antonio, 1976 - 1977

Awards:

Best Doctors in America Award, 1999, 2000, 2001

Publications:

Fluorescent Technique for Identification of M.D. Candida Albicans from Skin Scrapings. Arch Derm. 108:426, 1973

Tinea Faciale: An Often Misdiagnosed Clinical Entity. Sou Med J. 68:331, 1974

Current Concepts of Toxic Epidermal Necrolysis. Sou Med J. 68:22, 1975

Urethral Diverticulum Presenting as a Penile Cyst. Arch Derm. 11:52, 1975

Tinea of the Ear Mimicking Chondritis. Cutis 25:536, 1979

Granuloma Fissuratum Masquerading as a Skin Tumor. Cutis 26:663, 1980

Efficacy of Minocycline Compared with Tetracycline Treatment of Acne Vulgaris. Arch Derm. 118:989-992, 1982

Common Skin Disorders: A Physician's Illustrated Manual With Patient Instruction Sheets-Book Review. J. Am. Acad. Of Derm. 9:642, 1983

Common Skin Disorders (book review) J. Am. Acad. Of Derm. 19:1146, 1988

Review Physicians Illustrated Manual With Patient Instructions Sheet: J. Am. Acad. Of Derm. 19:1198, Dec. 1988

Exhibit - Mupirocin vs. Cephalexin: Double Blind Evaluation. Interscience Conference of Antimicrobial Agents Chemotherapy. New Orleans, Louisiana, October 1996

Treatment with a Novel Combination Erythromycin/Benzoyl Peroxide Gel System Significantly Improves the Signs of Acne Vulgaris. D. Thiboutot, MD; M. Jarratt, MD; P. Rich, MD; T. Rist, MD; et al (abstract-American Academy of Dermatology 59th Annual Meeting. Washington DC 3/2/2001 - 3/7/2001.

Histological effects of tazarotene cream 0.1% versus vehicle in photo-
damaged skin. L Machtinger, MD; K. Kaidbey, MD; J. Lim, MD; K
Loven, MD; T. Rist, MD; D. Wilson,MD; D. Parizadeh, MD; J. Sefton, MD; M. Holland ,MD; and P. Walker, MD.(Abstract-American Academy of Dermatology 2002 Meeting)

Subcutaneous Efalizumab (anti-CD11a) Is Effective in the Treatment of Severe to Moderate Plaque Psoriasis: Pooled Results of Two Phase III Clinical Trials. AB Gottlieb, K Papp, CW Lynde, W Carey, J Powers, TE Rist, E Rafal, M McCune, NH Shear, JP Ouellet, C Leonardi. (Abstract-American Academy of Dermatology 2002 Meeting.

Efficacy and Tolerability of Combined Topical Treatment of Acne Vulgaris with Adapalene and Clinicamycin: a Multicenter, Randomized, Blinded Study. Wolf J., Kaplan D., Draus S., Loven K., Rist T., Swinyer L., Baker M., Liu Y., and Czernielewski J. (Impress)

Erythromycin/Benzoyl Peroxide Pak: Comparable Efficacy to the Currently Marketed Product for the Treatment of Acne Vulgaris. Jarratt M., MD, Rich P., MD, Rist, T., MD, Thiboutot D., MD, Rodriguez, D., MD (Presented at the 60th Annual Meeting of the AAD, February 22-27, 2001)

A Randomized Study Comparing the Efficacy and Safety of a Novel Erythromycin/Benzoyl Peroxide Preparation or Vehicle Control for Acne Vulgaris. Thiboutot, D., Jarratt M. MD, Rich, P. MD, Rist, T. MD, Rodriguez, D. MD and Levy, S. MD (Clinical Therapeutics, March, 2002)

Histological effects of tazarotene cream 0.1% versus vehicle in photodamaged skin. A 6-month, multi-center, double-blind, parallel-group study in patients with photodamaged facial skin. Machtinger LA, Kaidbey K, Lim J, Loven KH, Rist TE, Wilson DC, Parizadeh D, Sefton J, Holland M, and Walker PS. (Poster for AAD June 2002 Meeting)

Effective Treatment of Actinic Keratosis with 0.5% Fluorouracil Cream for 1, 2, or 4 Weeks. Weiss, J, Menter, A, Heviao, Jones, T, Ling, M, Rist, T, (Cutis, August, 2002, Volume 70)

A Comparison of the Efficacy and Safety of Mupirocin Cream and Cephalexin in the Treatment of Secondarily Infected Eczema. Rist T, Parish, LC, Capin LR, Sulka V, Bushnell WE, Cupo MA. (Clinical and Experimental Dermatology 2002. In press)

"Histological Effects of Tazarotene 0.1% Cream Versus Vehicle on Photodamaged Skin. A 6-Month , Multicenter, Double-Blind, Vehicle-Controlled Study in Patients with Photodamaged Facial Skin" (Archives of Dermatology, November 2002.)

Study Design and Selection Criteria in a Large, Open-Label, Patient
Satisfaction Trial Evaluating Treatment of Mild to Moderate Acne
With Benzoyl Peroxide/Clindamycin topical Gel. Toivo Rist, MD
Matthew W. Davis, MD. Cutis: (In Press)

"Study Design and Selection Criteria in the BEST Study." Toivo Rist,
MD. Matthew W. Davis, MD. Cutis: Feb, 2003 (In Print)

"A Lidocaine 7% and Tetracaine 7% (LT) Peel Provides Clinically
Useful Local Anesthesia for Vascular Access Procedures in Adult
Subjects". Toivo Rist, MD.Accel Medical Education.

"A Peel (Lidocaine 7% and Tetracaine 7%) Versus EMLA® Cream for Induction of Local Anesthesia Prior to Minor Dermatological Procedures in Pediatric Subjects". Toivo Rist, MD. National Association of Pediatric Nurse Practitioners for the annual meeting.

"A Lidocaine 7% and Tetracaine 7% Peel for Local Anesthesia Prior to Lidocaine Injection in Pediatric Patients". Toivo Rist, MD. National Association of Pediatric Nurse Practitioners for the annual meeting.

"A Lidocaine 7% and Tetracaine 7% Peel for Local Anesthesia Prior to Vascular Access Procedures in Adults". Toivo Rist, MD, American Academy of Dermatology National Meeting, New Orleans, LA, Feb., 2005

"A Peel (Lidocaine 7% and Tetracaine 7%) Versus EMLA Cream for Induction for Induction of Local Anesthesia Prior to Minor Dermatological Procedures in Pediatric Subjects", Toivo Rist, MD, NAPNAP Annual Meeting, 2005.

" The use of Clobetasol Propinate 0.05% Lotion in the Treatment of Moderate to Severe Atopic Dermatitis", Toivo Rist, MD et all, Journal of Drugs in Dermatology, May/June 2005.

Laser Cases:

Argon
CO2
Pulse Dye
Q-Switched YAG
Ultra Pulse CO2
Laser Cases to Date: 5000+

Research Experience:

(Last ten years only - revised September, 2004)

A Multi-Center, Double-Blind, Randomized, Vehicle-Controlled, Parallel-Group Study To Determine The Therapeutic Equivalence Of Two Gel Formulations In Subjects With Rosacea.

A Randomized, Double-Blind, Parallel-Group, Multi-Center, Vehicle-Controlled Study Of A Topical Cream Applied Once Daily And Twice Daily In The Treatment Of Atopic Dermatitis.

A Multi-Center, Double-Blind, Randomized, Vehicle-Controlled, Parallel-Group Study Comparing A Generic Topical Suspension To A Currently Approved Medication, And Both Active Treatments To A Vehicle In The Treatment Of Acne Vulgaris.

Evaluation Of The Efficacy And Safety Of Twice Daily Application Of An Ointment And Its Vehicle In The Treatment Of Chronic Plaque Psoriasis.

A 12-week, Multi-Center, Double-Blind, Randomized, Parallel Design Study Of A Topical Gel And Vehicle Control In Patients With Acne Vulgaris.

Comparative Safety and Efficacy of an Antibiotic and Erythromycin with Mild to Moderate Skin or Skin Structure Infection.

An Antibiotic versus Erythromycin Base in Bacterial Skin / Skin Structure Infections.

A Double Blind, Double-Dummy, Randomized, Acyclovir Controlled, Parallel Group Study to Compare the Safety and Efficacy of an Antiviral with Acyclovir in the Treatment of Patients with Uncomplicated Herpes Zoster.

Evaluation of an Antiviral versus Placebo on Herpes Zoster Induced Pain (including post-herpetic neuralgia). A Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Multi-Center Study.

Double-Blind, Vehicle-Controlled Study of an Anti-Fungal Lacquer Applied Twice Weekly to Patients with Distal Subungual Onychomycosis of the Toenails Present for more than Five Years.

Double-Blind, Vehicle-Controlled Study of an Anti-Fungal Lacquer Applied Daily to Patients with Distal Subungual Onychomycosis of the Toenails Present for more than Five Years.

Double-Blind, Randomized, Placebo-Controlled, Parallel Group Study to Assess the Efficacy of an Antiviral in Ameliorating or Preventing Zoster Associated Pain in Patients Treated During the Acute Uncomplicated Zoster Attack.

Double-Blind, Randomized Study to Asses the Quality of Life and Cost of Disease In Patients with herpes Zoster Treated with an Antiviral or Placebo.

Randomized, Double-Blind, Double-Dummy, Multi-Center Comparative Study of the Efficacy and Safety of Antibiotic in the Treatment of Secondarily Infected Eczema.

Double-Blind, Multi-Center Study comparing Antivirals for the Treatment of Uncomplicated Herpes Zoster in Immunocompetent patients 50 Years of Age and Older.

A Randomized Controlled Study to Evaluate the Contribution of Injectable Components in an Antineoplastic Gel in Patients with Basal Cell Carcinoma.

Randomized, Double-Blind, Double-Dummy, Multi-Center Comparative Study of the Efficacy and Safety of Antibiotic in the Treatment of Secondarily Infected Open Wounds.

A Five Year Observation Study to Evaluate Clinical Response and Recurrence Rate in the Treatment of Basal Cell Carcinoma with an Antineoplastic Injectable Gel.

A Phase III Study of the Safety and Efficacy of an Anti-Viral in Subjects with Moderate to Severe Atopic Dermatitis.

A Multi-Center, Double-Blind, Randomized, Placebo-Controlled, Parallel Study Comparing the Efficacy and Safety of Four Dosage Strengths of An Antihistamine in the Treatment of Chronic Idiopathic Urticaria.

A Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of A Topical Steroid Foam in Treating Scalp Psoriasis.

A Randomized, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of An Oral Antiviral in Patients with Recurrent Genital Herpes.

A Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of An Antiviral in Patients with Recurrent Herpes Labialis.

A Double-Blind, Randomized Placebo-Controlled, Multi-Center, Parallel Group Evaluation of the Efficacy and Safety of a Topical Cream in Patients with Interdigital Tinea Pedis.

A Multi-Centered Controlled, Double-Blind, Comparative Study of the Safety and Efficacy of a Topical Gel in Treatment of Acne.

A Vehicle-Controlled, Randomized, Double-Blinded Study Comparing the Safety and Efficacy of a Topical Cream in Patients with Actinic Keratosis.

A Multi-Center, Double-Blind, Randomized, Vehicle-Controlled Study of the Safety and Efficacy of a Topical Cream in the Treatment of Plaque Psoriasis.

A Double-Blind, Active and Placebo-Controlled Study of the Safety and Efficacy of a Topical Foam in the treatment of Scalp Psoriasis.

Comparative Safety and Efficacy of and Oral Antibiotic in the Treatment of Patients with Uncomplicated Skin or Skin Structure Infection.

A Multi-Center, Randomized, Double-Blind, Parallel Group Vehicle-Controlled Study of the Efficacy and Safety of a Topical Lotion in the Treatment of Adult and Pediatric Subjects with Moderate to Severe Atopic Dermatitis.

A Single Dose and Multiple Dose, Escalading Dose Study to Evaluate the Safety, Pharmacokinetics, and Biological Activity of a Subcutaneous Injection in Subjects with Moderate to Severe Plaque Psoriasis.

A Multi-Center, Double-Blind, Vehicle-Controlled Study to Evaluate a Topical Gel in the Treatment of Mild to Moderate Distal Subungual Onychomycosis of the Toenail. Multi-Center, Double-blind, Randomized, Vehicle-Controlled, Parallel-Group Study of the Safety and Efficacy of a Topical Ointment in the Prevention of Cheilitis Associated with Oral Therapy in Severe Nodular Acne Patients.

A Multi-Center, Double-Blind, Randomized, Vehicle-Controlled, Parallel group Study of the Safety and Efficacy of a Topical Cream in Patients with Acne Vulgaris.

An Open Label Study to Evaluate the Safety of Topically Applied Ointment for the Treatment of Atopic Dermatitis.

A Randomized, Double-Blind, Placebo-Controlled Study Evaluating a Dermal Anesthetic Peel for Induction of Local Anesthesia Prior to Pulsed Dye Laser Therapy in Adult Subjects.

A Multi-Center, Double-Blind, Randomized, Parallel-Group Study of the Histological Safety Profile of a Retinoid Cream versus Vehicle Applied Once Daily for up to 24 Weeks in Patients with Photodamaged Facial Skin.

The Safety and Efficacy of a Steroid Lotion as Compared to its vehicle and a Steroid Cream in the Treatment of Moderate to Severe Atopic Dermatitis.

Multi-Center, Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Dose Response, Safety and Efficacy Study of 24 Week Treatment with an oral Medication and 12 Week Post-Treatment Follow-Up in Patients with Severe Nodulocystic Acne.

A Randomized, Double-Blind, Multi-Center, Comparative Study of an Oral
Antibiotic versus Oral Antibiotic in the treatment of uncomplicated skin and
Soft tissue infections.

A Clinical Study to Evaluate the Safety and Efficacy of an Anti-Fungal Cream
versus a Vehicle Cream in the Treatment of Plantar Tinea Pedis.

A 12-Week, Randomized, Double-Blind, Multicenter study comparing the Clinical Efficacy and Safety of a Topical Gel with its Vehicle in Patients with Moderate, Papulopustular Facial Rosacea.

A Phase II Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose, Dose-and-Schedule-Finding, Safety and Efficacy Study of an Intravenous Medication in Patients with Moderate to Severe Plaque Psoriasis.

A Phase II Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose, Dose-Finding, Safety, and Efficacy Study of a Primatized Monoclonal Antibody in Patients with Moderate to Severe Plaque Psoriasis.

A Phase III, Vehicle Controlled Study of a Topical Gel applied Twice Weekly for Three Weeks for Each Recurrence of Herpes Genitalis over 12 Months.

A Multi-Center, Open-Label Safety Study of an Oral Capsule Once Daily in Patients with Moderate to Very Severe Psoriasis.

A Double-Blind, Placebo Controlled Study of the Recurrence and Re-treatment of Actinic Keratoses After One Week Treatment with a Topical Cream.

A Vehicle-Controlled, Randomized, Double-Blind, Multi-Center Study of the Efficacy and Safety of a Shampoo in the Treatment of Seborrheic Dermatitis of the Scalp.

A Multi-Center, Double-Blind, Placebo Controlled, Parallel Group Study Comparing the Bioequivalence of a Generic Formulation of a gel in the Treatment of Inflammatory Papules and Pustules of Rosacea.

A 12-Month, Multicenter, Open-Label, Non-Comparative Design Study of a Topical Gel in Patients with Acne Vulgaris.

A Multi-Center, Randomized, Placebo-Controlled Phase 2 Study Evaluating
the Effect of an Intradermal Injection Compared to Placebo in Patients with
Psoriasis.

A Randomized, Third Party Blind, Multicenter Trial Comparing the Efficacy and Safety of an Oral Med for 3 Weeks Versus a Second Oral Med for 6 Weeks Versus a Third Oral Medication for 6 Weeks Given Once Daily to Pediatric Patients with Tinea Capitis.

A Phase IIIb, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multicenter Study to Evaluate the Safety of a Subcutaneously Administered Medication in Adults with Moderate to Severe Plaque Psoriasis who are Candidates for Systemic Therapies.

An Open Label, Multicenter Trial of an Oral Medication for 6 Weeks Given Once Daily to Pediatric Patients with Tinea Capitis.

Evaluation of the Efficacy and Safety of Twice Daily Application of an Ointment and its Vehicle, in the Treatment of Chronic Plaque Psoriasis.

An Open Label, Multi-Center, Phase IV study of a Medication for the Treatment of Mild to Moderate Acne Vulgaris.

A Twelve Week, Randomized, Double Blind, Multi-Center Study Comparing the Clinical Efficacy and Safety of an Acid in its Gel with its Vehicle in Patients with Mild to Moderate Acne.

A Vehicle Controlled, Double Blind Study to Assess the Safety and Efficacy of a Cream Applied Once Daily 3 days per Week for the Treatment of Actinic Keratoses on the Head.

A Randomized, Double Blind, Placebo Controlled Study Evaluating a Patch for Induction of Local Anesthesia for Lidocaine Injection in Pediatric Patients.

A 12 Week, Multi-Center, Double Blind, Randomized, Parallel Design Study of a Topical gel and its vehicle in Patients with Acne Vulgaris.

A Multi-Center, Double-Blind, Randomized, Vehicle Controlled, Parallel Group Study to Determine the Therapeutic Equivalence of Two Gel Formulations in the Treatment of Rosacea.

A Multi-Center, Randomized, Double-Blind, Vehicle-controlled, Dose-finding Bilateral Plaque Comparison Study of the Safety and Efficacy of Three Concentrations of an Ointment in the Treatment of Mild to Moderate Plaque Psoriasis.

A Phase IIIb, Multi-Center, Open-Label, Prospective Study To Evaluate The Effectiveness And Safety Of A Subcutaneously Injected Medication In The Treatment Of Subjects With Psoriasis.

A Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Multi-Center Study To Compare The Clinical Equivalence Of A Generic Topical Gel To A Currently Approved Medication In Subjects With Moderate To Severe Acne Rosacea.

A Randomized, Double-Blind, Placebo-Controlled, Phase III Study Of An Extended-Release Formulation Of An Oral Medication For The Treatment Of The Inflammatory Lesions of Acne Vulgaris.

A Phase IIIb, Open-Label Effectiveness and Safety Study Of A Topical Cream In The Treatment Of Actinic Keratosis.

A Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Multi-Center Study To Compare The Clinical Equivalence Of A Generic Topical Gel To A Currently Approved Medication In Subjects With Moderate To Severe Acne Rosacea.

A Phase IV, Multi-Center, Open-Label, Randomized Study of the Safety and Efficacy of a Low-Dose Oral Medication for the Treatment of Moderate to Severe Plaque-Type Psoriasis.

An Open-Label Safety Study of a New Formulation of an Oral Medication for Treatment of Moderate to Severe Acne.

A Randomized, Double-Blind, Placebo Controlled, Parallel Design, Multi-Site Clinical Study to Evaluate the Bioequivalence of a Topical Gel Formulation in Patients with Moderate to Severe Rosacea.

An Open-Label, Community-Based Study to Determine the Safety and Efficacy of an Extended Course of an injection which follows a Standard 12-Week course for the Treatment of Psoriasis.

A Randomized, Double-blind, Double-dummy, Multicenter, Phase III Study to Assess the Safety and Efficacy of a Topical Ointment versus an Oral Antibiotic in the Treatment of Secondarily-infected Dermatoses.

A Multicenter, Randomised, Double-blind, Placebo controlled, Phase III study of a Subcutaneously Administered Study Drug in the Treatment and Re-treatment of Subjects with Moderate to Severe Plaque Psoriasis.

A 5 year Assessment and Tracking of a Long-term Safety Study with a FDA approved IM Injection in Subjects with Moderate to Severe Chronic Plaque Psoriasis.

A Randomized, Double Blind, Parallel Group, Multicenter, Phase 3 Extension, Efficacy and Safety Study of Nail Lacquer or Placebo Combined with Oral Lamisil in the Treatment of Onychomycosis.

An Open Label, Single Group, Multicenter, Phase 3 Extension Study to Assess the Maintenance Use of Nail Lacquer in the Treatment of Onychomycosis.

A 10 Year Prospective Pediatric Evaluation to Assess the Long-Term Safety of an Ointment for the Treatment of Atopic Dermatitis.

A Multicenter, Prospective, 5-year Surveillance Study of an IM medication for Subjects with Chronic Moderate to Severe Plaque Psoriasis.

A Randomized, Double-Blind, Vehicle-Controlled Study of the Safety and Efficacy of a Study Foam versus an FDA approved Cream in the Treatment of Seborrheic Dermatitis.

A Phase 4, Double-Blind, Multicenter, Randomized, Vehicle-Controlled, Cross-Over Study to Further Evaluate the Risk of Hematological Adverse Events in G6PD-Deficient Subjects with Acne Vulgaris treated with a Gel.

A Randomized, Double-Blind, Placebo Controlled, Parallel Design, Multiple-Site Study to Evaluate the clinical Equivalence of Two Shampoos in Patients with Tinea (Pityriasis) Versicolor.

A Phase III, Multi-Center, Randomized, Double-Blind, Vehicle Controlled, 4-Arm Parallel Group Comparison Study Comparing the Efficacy and Safety of a Gel with Vehicle Gel in the Treatment of Moderate to Severe Acne Vulgaris.

A Phase III, Randomized, Evaluator-Blind, Parallel Group Study of the Efficacy and Safety of a Tablet, Capsule, and Placebo in the Treatment of Onychomycosis of the Toenail.

A Randomized, Double-Blind, Placebo Controlled, Parallel Design, Multiple-Site Study to Evaluate the Clinical Equivalence of Two Cream in Patients with Interdigital Tinea Pedis.
A Randomized, Double- Blind, Placebo Controlled, Parallel Design, Multi-Site Study to Evaluate the Bioequivalence Two Ointments and Placebo in Patients with Moderate to Severe Psoriasis.

A Multi-Center, Randomized, Double-Blind, Parallel-Group Study to Demonstrate the Efficacy and Safety of a Medicated Topical Gel Compared with Two Different Strengths of Medicated Topical Gel and a Topical Gel Vehicle in Subjects with Acne Vulgaris.

A Phase 2, Multi-Center, Randomized, Double-Blind, Vehicle-Controlled, Dose-Ranging Clinical Study to Evaluate the Safety and Efficacy of a Topical Cream Applied Twice Daily for 12 Weeks for the Treatment of Facial Acne Vulgaris.
A Multi-Center, Randomized, Double-Blind, Parallel Group Study to Demonstrate the Efficacy and Safety of a Lotion Compared With Vehicle Lotion in Subjects with Acne Vulgaris.

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