KNOXVILLE, Tenn. (WATE) – Eastbound lanes of I-40 have reopened as rescue crews are working a wreck in which the vehicle left the interstate.

It happened just before 11 a.m. around mile marker 406, just short of the exit to Sevierville. A Sevierville Police spokesperson said it is a serious injury crash and a Lifestar helicopter took off from the scene.

The number of people involved is unknown at this time.

Tennessee Department of Transportation Spokesperson Mark Nagi said all lanes reopened around 12:15 p.m.

This is a developing story and we’ll continue to update the details as they become available.