A string of crashes closed Interstate 40 West in Henderson County, about 80 miles west of Nashville.
The crash was reported around 12:30 p.m. Central time near Natchez Trace State Park on the snow-covered roadway.
Multiple vehicles were involved, including tractor-trailers and a TDOT Help truck. As of this time, there are no reports of injuries.
The westbound lanes were completely closed as crews worked to clear the area, causing traffic to back up for several miles.
The crash was finally cleared just after 11 p.m, but crews then began working on removing dozens of stalled vehicles and getting traffic flowing, which the Tennessee Highway Patrol said would take several more hours to complete.
Eastbound traffic was not affected.
The Tennessee Emergency Management Agency has declared a level three state of emergency as winter weather impacts the interstates in Tennessee.
So far there are no reports of widespread power outages or weather-related fatalities. The Red Cross has shelters on standby